Proteins+and+Mutations

__**Assessment statements**__ Protein Structure 3.6.4 Define denaturation. 7.4.5 Draw and label a diagram showing the structure of a peptide bond between two amino acids. 7.5.1 Explain the four levels of protein structure, indicating the significance of each level. 7.5.3 Explain the significance of polar and non-polar amino acids.
 * Proteins and Mutation Unit Plan** //**(5 days)**//

Protein Function 7.5.2 Outline the difference between fibrous and globular proteins, with reference to two examples of each protein type. 7.5.4 State four functions of proteins, giving a named example of each. Mutations 4.1.3 Define gene mutation. 4.1.4 Explain the consequence of a base substitution mutation in relation to the processes of transcription and translation, using the example of sickle-cell anemia.

__**What You Need to Know**__ > ** Protein Structure ** > Draw the generalized amino acid structure, identifying the amino group, the carboxyl group, the radical group, and the alpha carbon. > Define what is meant by “essential amino acid.” > Explain how the characteristics of R groups (polar, non-polar, and ionic) affect their behavior in protein folding. > Describe polypeptide chain formation in terms of the formation of peptide bonds and condensation reactions. > Determine the number of peptide bonds given the number of amino acids in a polypeptide. > Describe the primary structure of a protein, including the type of bonding involved. > Describe the secondary structure of a protein, including the type of bonding involved. > Describe the tertiary structure of a protein, including the types of bonding involved. > Describe the quaternary structure of a protein. > Explain the role of chaperones in protein folding. > Contrast the structure of globular proteins with the structure of fibrous proteins. > Define denaturation and list conditions that can cause it to happen. > ** Protein Function ** > Define proteomics. > Contrast the generalized function of globular proteins with generalized function of fibrous proteins. > List and describe examples of fibrous proteins used in structure and support. > List and describe examples of fibrous proteins used for movement and contraction. > List and describe examples of globular proteins used for storage. > List and describe examples of globular proteins used for transport. > List and describe examples of globular proteins used as hormones. > List and describe examples of globular proteins used as receptors. > List and describe examples of globular proteins used in defense against disease. > List and describe examples of globular proteins used as enzymes. > Explain the role of mis-folded proteins in disease (specifically Alzheimer’s). > ** Mutations ** __**Unit Activities List:**__ > [|Amino acid packet] (doc) > [|Protein structure and function notes] (doc) > [|Protein structure and function notes notes] (ppt) > Protein structure role play > Mystery of protein folding article > [|Proteins rule article] (pdf) > [|Proteins rule reading questions] (doc) > [|Protein toober lab] (doc) > [|Protein molecular visualization] (doc) > [|Foldit] > Protein function memory match > Mutation notes > Mutation worksheet > [|Mutations packet] (pdf)

__**Helpful Links:**__ > ** Protein Structure ** > [|Amino Acid and Peptide Bond Animation] > [|Life Cycle of a Protein] > [|Heat Changes a Protein Structure] > [|Protein Secretion] > [|Biomolecules: Proteins] > [|Acideroids game] > ** Mutation ** > [|Mutation by Base Substitution] > [|Addition and Deletion Mutations] > [|Mutation]

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